Cam Skattebo rushed for 177 yards on 21 carries with three touchdowns to lead No. 16 Arizona State to a 49-7 victory Saturday over archrival Arizona in Tucson, Ariz.

Arizona State (10-2, 7-2 Big 12) has put itself in potential position to play in the conference championship game with the victory, the Sun Devils’ first win against Arizona since 2021.

Arizona (4-8, 2-7) ended coach Brent Brennan’s first season losing seven of its last eight games.

The Wildcats allowed Arizona State 643 yards in total offense while they mustered 210.

Skattebo had 113 of his yards and his three touchdowns in the first half when Arizona State led 35-0.

Kyson Brown rushed eight times for 100 yards.

Sam Leavitt completed 17 of 22 pass attempts for 291 yards with three touchdowns and no interceptions.

Backup Trenton Bourguet, a Tucson native, completed 2 of 3 passes for 71 yards and a touchdown in his return home.

Arizona receiver Tetairoa McMillan, a projected NFL first-round draft pick, likely played his last game in college.

He finished with six receptions for 68 yards and a touchdown.

Noah Fifita, a preseason Heisman hopeful, completed 14 of 29 pass attempts for 126 yards with a touchdown and no interceptions.

Arizona State scored a touchdown on its first four possessions to take control, leading 28-0 with 6:28 left in the second quarter.

Skattebo scored three of those touchdowns and Leavitt connected on a 13-yard touchdown pass with Jordyn Tyson for the other score.

Arizona State extended the lead to 35-0 with 41 seconds left in the half on a 22-yard pass from Leavitt to Chamon Metayer.

Arizona scored its lone touchdown taking the first possession of the second half 75 yards on eight plays, capped by Fifita’s 28-yard pass to McMillan.

The Wildcats had a chance to cut into the lead more after Arizona State’s Parker Lewis missed a 21-yard field goal.

Arizona was forced to punt on its next possession.

Arizona State extended the lead to 42-7 with 14:55 left on a 31-yard pass from Leavitt to Xavier Guillory. Bourguet had the final score, a 64-yard scoring toss to Derek Eusebio.